Browse Skills — Page 109

epitranscriptomics-m6a-differential

swaruplab/operon

Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` + `bam_treated_input` (treatment arm) for integrated GC-bias-aware differential calling (Liu 2022 *NAR Genom Bioinform* 4:lqac046), QNB beta-binomial test (Liu 2017 *BMC Bioinformatics* 18:387), MeTDiff HMM-based differential bundled with MeTPeak, RADAR (Zhang 2019 *Genome Biol* 20:294) with its `filterBins -> diffIP -> reportResult` workflow, and the defensible paired-symmetric case of edgeR / DESeq2 on featureCounts-on-peaks matrices when batch / lot covariates need explicit fixed-effect handling (exomePeak2's top-level API does NOT accept arbitrary covariates). Covers paired vs unpaired vs interaction designs, batch confounding (antibody lot, RNA prep, sequencing run) and the per-lot meta-analysis strategy when exomePeak2 is the primary caller, the stoichiometry-vs-expression-vs-IP-efficiency confound that all MeRIP differential methods inherit, normalisation choice (size factor on IP, on input, on per-sample IP/input ratio), the McIntyre 2020 reproducibility caveat, effect-size filtering as a guardrail against under-powered N=2 designs, and orthogonal-validation routes for absolute stoichiometry (GLORI / SAC-seq / m6Anet `mod_ratio`). Use when comparing m6A levels across two or more conditions, choosing between exomePeak2 / QNB / RADAR / MeTDiff for a given design, handling batch confounding when exomePeak2's API is too rigid, normalising against input properly, distinguishing real hyper- / hypo-methylation from expression-level shifts, applying effect-size thresholds, interpreting volcano plots of differential peaks, or planning a follow-up orthogonal stoichiometry validation.

epitranscriptomics-m6a-peak-calling

swaruplab/operon

Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM; Liu 2022 *NAR Genom Bioinform* 4:lqac046), MeTPeak (HMM over sliding windows; Cui 2016 *Bioinformatics* 32:i378), MACS3 / MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment confirmation via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output formats, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union; cross-caller IDR-equivalent), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody-based methods cannot resolve, and orthogonal-validation routes (miCLIP / GLORI / m6A-SAC-seq / m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set as a whole, reconciling differing peak sets across tools, validating MeRIP peaks against orthogonal single-base methods, interpreting peaks at the 5' end where m6Am contamination is possible, or recommending a multi-tool consensus strategy.

epitranscriptomics-m6anet-analysis

swaruplab/operon

Detects m6A modifications from Oxford Nanopore direct-RNA-sequencing (ONT DRS) signal data using m6Anet (Hendra 2022 *Nat Methods* 19:1590; multiple-instance-learning neural network over DRACH 5-mer signal). Covers the required upstream pipeline (Dorado / Guppy basecalling -> minimap2 transcriptome alignment with `-ax map-ont -uf -k14 --secondary=no` -> nanopolish eventalign with `--scale-events --signal-index` (m6Anet-required) plus `--summary` / `--threads` housekeeping -> m6anet dataprep -> m6anet inference), per-site vs per-read probability interpretation including the `mod_ratio` per-site stoichiometry column, the DRACH-only modeling constraint, minimum-coverage thresholds (20-50 reads per site for stable probability estimates), multi-condition comparison via xPore (Pratanwanich 2021 *Nat Biotechnol* 39:1394), Nanocompore (Leger 2021 *Nat Commun* 12:7198), ELIGOS (Jenjaroenpun 2021 *NAR* 49:e7), and Dorado native modification calling (RNA004 chemistry, 2024+), reference-transcriptome version pinning, the cDNA-vs-DRS chemistry distinction (cDNA-Nanopore CANNOT be used for modification detection), and orthogonal validation against MeRIP / GLORI. Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting per-site `probability_modified` vs `mod_ratio` vs per-read modification probabilities, comparing methylation between conditions from ONT data, deciding between m6Anet for known DRACH sites and Dorado/Remora for genome-wide screening, pinning RNA002 vs RNA004 chemistry and basecaller model versions, or troubleshooting eventalign / dataprep failures.

epitranscriptomics-merip-preprocessing

swaruplab/operon

Aligns and QCs methylated-RNA-immunoprecipitation (MeRIP / m6A-seq) IP and input libraries using STAR or HISAT2 splice-aware mapping, samtools sort/index, IP/input matched-pair tracking, antibody-lot metadata recording, replicate concordance via deepTools multiBamSummary + plotCorrelation, IP enrichment QC via plotFingerprint and per-transcript IP/input ratio distributions, library-complexity saturation curves via PreSeq c_curve / lc_extrap, and the explicit do-NOT-deduplicate convention for standard non-UMI MeRIP. Use when preparing paired IP and input BAM files for exomePeak2 / MeTPeak / MACS3 peak calling, evaluating MeRIP replicate concordance and IP enrichment, deciding whether to deduplicate (standard MeRIP typically NOT — see Tips), choosing genome-vs-transcriptome alignment for downstream peak vs m6Anet workflows, recording antibody clone and lot metadata for downstream cross-batch reconciliation, detecting failed IPs via saturation curves and IP/input distribution shape, or generating IP-over-Input bigWig tracks for downstream visualisation.

epitranscriptomics-modification-visualization

swaruplab/operon

Visualises RNA-modification data with transcript-feature metagene plots (Guitar GuitarPlot with 5'UTR / CDS / 3'UTR scaling; MetaPlotR; deepTools `computeMatrix scale-regions`), peak-centred heatmaps (ComplexHeatmap; deepTools plotHeatmap), IP-vs-input paired browser tracks (bigWig of log2 IP/input via deepTools `bamCompare`; ggcoverage; pyGenomeTracks; Gviz; IGV / UCSC track hubs), DRACH sequence-logo plots (ggseqlogo; MEME), 5'UTR / CDS / 3'UTR stacked-bar feature-distribution summaries, and volcano / MA plots for differential modification. Establishes stop-codon enrichment in the metagene plot as the biological QC anchor for any MeRIP dataset (Dominissini 2012 *Nature* 485:201; Meyer 2012 *Cell* 149:1635 — concurrent founding papers from different labs both showed this independently). Use when producing the canonical metagene plot with stop-codon enrichment as a QC anchor, building paired IP/input genome-browser tracks at single-locus resolution, plotting peak-centred heatmaps clustered by condition, summarising peak distribution across transcript features for figure 1, generating DRACH motif logos as sanity checks on the peak set, rendering volcano plots of differential m6A, or reproducing the Dominissini 2012 / Meyer 2012 stop-codon enrichment plot.

ePub Accessibility

Community-Access/accessibility-agents

ePub document accessibility specialist. Use when scanning, reviewing, or remediating .epub files for accessibility. Covers EPUB Accessibility 1.1 (WCAG 2.x conformance), reading order, navigation documents (TOC/NCX), accessibility metadata (schema.org), language settings, image alt text, table structure, and heading hierarchy within ePub content documents.

epub-scan-config

Community-Access/accessibility-agents

Manages .a11y-epub-config.json scan configuration for ePub accessibility audits. Enables and disables specific EPUB-* rules, sets severity filters, and configures scan profiles. Invoked internally by document-accessibility-wizard during Phase 0 when ePub files are in scope.

eqtl-catalogue-skill

openai/plugins

Submit compact eQTL Catalogue API requests for association retrieval and documented metadata endpoints. Use when a user wants concise public eQTL Catalogue summaries

equipment-fleet-manager

datadrivenconstruction/DDC_Skills_for_AI_Agents_in_Construction

Manage construction equipment fleet. Track utilization, maintenance, and assignments.

equipment-maintenance-log

aipoch/medical-research-skills

Track lab equipment calibration dates and send maintenance reminders for pipettes, balances, centrifuges, and other instruments. Validates date formats and supports update/delete operations.

equipment-telematics

datadrivenconstruction/DDC_Skills_for_AI_Agents_in_Construction

Integrate and analyze telematics data from heavy construction equipment. Track location, utilization, fuel consumption, maintenance needs, and operator behavior.

equity-model-update

openai/plugins

Safely update public-company Excel model copies from source-to-model maps; emits XLSX as the hero artifact and CSV/log/manifest as support. Do not use for pure earnings notes or broad workbook audits.

equity-research

anthropics/financial-services

Generate comprehensive equity research snapshots combining analyst consensus estimates, company fundamentals, historical prices, and macroeconomic context. Use when researching stocks, comparing estimates to actuals, analyzing company financials, assessing equity valuations, or building investment cases.

equity-researcher

lzwme/finance-quant-skills

机构级投研报告生成技能。覆盖中国A股、港股、美股上市公司。输出模式：1）投资速览：3-5页，含公司概览、核心财务指标、估值倍数、投资逻辑与风险因素；2）深度研报：≥25页，含行业分析、产业链图谱、三表模型、DCF估值、情景分析与敏感性测试。触发条件：1）直接请求：分析/看看/研究/调研/介绍一下 + 公司名或股票；2）投资询问：你怎么看/能不能买/值得投吗/帮我看看/扒一扒 + 公司或股票；3）关键词：研报、投资简报、投资速览、公司一页纸、深度研报、深度研究、深度分析、个股分析、一页纸、速览、公司速览、投研报告；4）股票代码：标准格式（如 600519.SH、0700.HK、AAPL、TSLA、BYD）。意图不明确时主动询问输出模式，禁止默认推断。

equity-scorer

aAAaqwq/AGI-Super-Team

Compute HEIM diversity and equity metrics from VCF or ancestry data. Generates heterozygosity, FST, PCA plots, and a composite HEIM Equity Score with markdown reports.

equivariant-architecture-designer

lyndonkl/claude

Designs neural network architectures that respect validated symmetry groups, recommending architecture families (G-CNN, steerable CNN, e3nn), layer patterns, and implementation libraries. Use when you have validated symmetry groups and need equivariant architecture design, or when user mentions equivariant layers, G-CNN, e3nn, steerable networks, or building symmetry into a model.

eradicating-malware-from-infected-systems

mukul975/Anthropic-Cybersecurity-Skills

Systematically remove malware, backdoors, and attacker persistence mechanisms from infected systems while ensuring complete eradication and preventing re-infection.

erc-8004

BankrBot/skills

Register AI agents on Ethereum mainnet using ERC-8004 (Trustless Agents). Use when the user wants to register their agent identity on-chain, create an agent profile, claim an agent NFT, set up agent reputation, or make their agent discoverable. Handles bridging ETH to mainnet, IPFS upload, and on-chain registration.

erfinderische-taetigkeit-pruefen

Klotzkette/claude-fuer-deutsches-recht

Prueft erfinderische Taetigkeit nach § 4 PatG und Art. 56 EPUe mit dem Problem-Solution-Approach der EPA-Beschwerdekammern. Drei Stufen: (1) Bestimmung des naechstliegenden Stands der Technik (closest prior art) anhand technischer Naehe Zweckverwandschaft und gemeinsamer Merkmale; (2) Formulierung der objektiven technischen Aufgabe (objective technical problem) als das was die Erfindung loest und der naechstliegende Stand der Technik nicht; (3) Frage nach could-would am Tag der Anmeldung haette der Fachmann ausgehend vom naechstliegenden Stand der Technik mit Erwartung auf Erfolg die beanspruchte Loesung umgesetzt. Beruecksichtigt Sekundaerindizien wie technisches Vorurteil unerwartete Wirkung lange empfundenes Beduerfnis und kommerziellen Erfolg. Disclaimer keine amtliche Pruefung.

erfindungsmeldung-aufnahme

Klotzkette/claude-fuer-deutsches-recht

Erstprüfung einer Erfindungsmeldung nach deutschem Recht — Neuheit, erfinderische Tätigkeit, technischer Charakter (EPÜ), Schutzfähigkeit, Arbeitnehmererfindung (ArbnErfG) und strategischer Wert. Lädt, wenn eine Erfindungsmeldung eingereicht wird und eine Ersteinschätzung zu Anmeldung, Weiterverfolgung oder Ablehnung benötigt wird.

erforderlichkeit-1-abs-3-baugb

Klotzkette/claude-fuer-deutsches-recht

Pruefung der staedtebaulichen Erforderlichkeit Paragraf 1 Abs. 3 S. 1 BauGB als materielle Wirksamkeitsvoraussetzung des Bebauungsplans. Bauleitplaene sind aufzustellen sobald und soweit es fuer die staedtebauliche Entwicklung und Ordnung erforderlich ist. Planrechtfertigung verlangt nachvollziehbares staedtebauliches Konzept. Gefaelligkeitsplanung zugunsten eines Privaten ist regelmaessig unzulaessig. Vorhabenbezogener B-Plan Paragraf 12 BauGB nicht automatisch Gefaelligkeitsplanung aber Vorfestlegungsindiz pruefen. Negativplanung als Verhinderungsplanung problematisch wenn ohne positives Konzept. Reine Investorinitiative ohne Aufnahme in gemeindliches Konzept Gefahr. Massstab BVerwG seit Urteil vom 11.3.1988 4 C 56.84. Strenge Pruefung gegenueber Abwaegungsfehlern Erforderlichkeit ist stets beachtlich und nicht ruegepflichtig nach Paragraf 215 BauGB.

erforderlichkeit-dokumentieren

Klotzkette/claude-fuer-deutsches-recht

Pruefe die Erforderlichkeit der Offenlegung von Berufsgeheimnissen gegenueber dem KI-Dienstleister nach Absatz eins der einschlaegigen Dienstleisterregelung (BRAO StBerG WPO PAO BNotO). Bezugspunkt ist nach DAV-Stellungnahme zweiunddreissig der Zweck der Offenlegung nicht die KI-Strategie der Kanzlei. Erstelle einen internen Compliance-Vermerk mit Beurteilungsspielraum und Grenzen.

erlang-concurrency

elizaOS/eliza

Use when erlang's concurrency model including lightweight processes, message passing, process links and monitors, error handling patterns, selective receive, and building massively concurrent systems on the BEAM VM.

erlang-distribution

elizaOS/eliza

Use when erlang distributed systems including node connectivity, distributed processes, global name registration, distributed supervision, network partitions, and building fault-tolerant multi-node applications on the BEAM VM.

erlang-otp-behaviors

elizaOS/eliza

Use when oTP behaviors including gen_server for stateful processes, gen_statem for state machines, supervisors for fault tolerance, gen_event for event handling, and building robust, production-ready Erlang applications with proven patterns.

ernie-image

artokun/comfyui-mcp

Build Baidu ERNIE-Image / ERNIE-Image-Turbo workflows — primarily TEXT-TO-IMAGE. Pick ERNIE when you need precise multilingual text rendering, posters/signage, manga/anime multi-panel layouts, or strong instruction following for complex multi-object scenes. Also supports denoise-based image-to-image refine (NOT instruction-grounded editing — use Qwen-Image-Edit or Flux Kontext for "change X in this photo" edits).

erp-data-extractor

datadrivenconstruction/DDC_Skills_for_AI_Agents_in_Construction

Extract and analyze data from construction ERP systems. Pull project data for analytics, reporting, and integration.

erp-integration-analysis

datadrivenconstruction/DDC_Skills_for_AI_Agents_in_Construction

Analyze ERP system integration for construction data flows. Map and optimize data flows between ERP modules

error-analysis

hamelsmu/evals-skills

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error-boundary-creator

OneWave-AI/claude-skills

Create error boundaries, error handling, and fallback UIs for React applications. Use when implementing error handling, creating fallback components, or setting up error reporting.

error-check

MicrosoftDocs/cloud-adoption-framework

Identifies severe factual errors in content. Use when asked to fact-check documentation for major inaccuracies.

error-debugging-error-analysis

benjaminasterA/antigravity-awesome-skills

You are an expert error analysis specialist with deep expertise in debugging distributed systems, analyzing production incidents, and implementing comprehensive observability solutions.

error-debugging-error-analysis-v2

diegosouzapw/awesome-omni-skills

Error Analysis and Resolution workflow skill. Use this skill when the user needs You are an expert error analysis specialist with deep expertise in debugging distributed systems, analyzing production incidents, and implementing comprehensive observability solutions and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

error-debugging-error-trace

benjaminasterA/antigravity-awesome-skills

You are an error tracking and observability expert specializing in implementing comprehensive error monitoring solutions. Set up error tracking systems, configure alerts, implement structured loggi...

error-debugging-error-trace-v2

diegosouzapw/awesome-omni-skills

Error Tracking and Monitoring workflow skill. Use this skill when the user needs You are an error tracking and observability expert specializing in implementing comprehensive error monitoring solutions. Set up error tracking systems, configure alerts, implement structured logging, and ensure teams can quickly identify and resolve production issues and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

error-debugging-multi-agent-review

benjaminasterA/antigravity-awesome-skills

Use when working with error debugging multi agent review

error-debugging-multi-agent-review-v2

diegosouzapw/awesome-omni-skills

Multi-Agent Code Review Orchestration Tool workflow skill. Use this skill when the user needs working with error debugging multi agent review and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

error-detective

benjaminasterA/antigravity-awesome-skills

Search logs and codebases for error patterns, stack traces, and

error-detective-v2

diegosouzapw/awesome-omni-skills

error-detective workflow skill. Use this skill when the user needs Search logs and codebases for error patterns, stack traces, and anomalies. Correlates errors across systems and identifies root causes and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

error-diagnostics-error-analysis

benjaminasterA/antigravity-awesome-skills

You are an expert error analysis specialist with deep expertise in debugging distributed systems, analyzing production incidents, and implementing comprehensive observability solutions.

error-diagnostics-error-analysis-v2

diegosouzapw/awesome-omni-skills

Error Analysis and Resolution workflow skill. Use this skill when the user needs You are an expert error analysis specialist with deep expertise in debugging distributed systems, analyzing production incidents, and implementing comprehensive observability solutions and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

error-diagnostics-error-trace

benjaminasterA/antigravity-awesome-skills

You are an error tracking and observability expert specializing in implementing comprehensive error monitoring solutions. Set up error tracking systems, configure alerts, implement structured logging,

error-diagnostics-error-trace-v2

diegosouzapw/awesome-omni-skills

Error Tracking and Monitoring workflow skill. Use this skill when the user needs You are an error tracking and observability expert specializing in implementing comprehensive error monitoring solutions. Set up error tracking systems, configure alerts, implement structured logging, and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

error-diagnostics-smart-debug

benjaminasterA/antigravity-awesome-skills

Use when working with error diagnostics smart debug

error-diagnostics-smart-debug-v2

diegosouzapw/awesome-omni-skills

error-diagnostics-smart-debug workflow skill. Use this skill when the user needs working with error diagnostics smart debug and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

error-handler

EliasOulkadi/shokunin

Design error handling, structured logging, and observability with OpenTelemetry (traces, metrics, logs), error classification, recovery patterns (retry with jitter, circuit breaker, bulkhead, timeout), error budgets/SLOs with burn rate alerts, and production incident triage. Use when user asks to implement error handling, logging, monitoring, observability, OpenTelemetry, error boundaries, circuit breakers, retry logic, or SLO tracking. Do NOT use for incident runbooks (use runbook-gen), vendor-specific APM setup (Datadog, Sentry agent config), or K8s debugging.

error-handling

affaan-m/ECC

Patterns for robust error handling across TypeScript, Python, and Go. Covers typed errors, error boundaries, retries, circuit breakers, and user-facing error messages.

error-handling-patterns

benjaminasterA/antigravity-awesome-skills

Master error handling patterns across languages including exceptions, Result types, error propagation, and graceful degradation to build resilient applications. Use when implementing error handling...

error-handling-patterns

wshobson/agents

Master error handling patterns across languages including exceptions, Result types, error propagation, and graceful degradation to build resilient applications. Use when implementing error handling, designing APIs, or improving application reliability.

error-handling-patterns-v2

diegosouzapw/awesome-omni-skills

Error Handling Patterns workflow skill. Use this skill when the user needs Build resilient applications with robust error handling strategies that gracefully handle failures and provide excellent debugging experiences and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

error-messages

github/gh-aw

Write consistent, actionable validation error messages in gh-aw.

error-monitoring

TerminalSkills/skills

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error-pattern-safety

github/gh-aw

Apply safe error-pattern matching rules for agentic engines.

error-recovery-patterns

github/gh-aw

Design gh-aw error handling, retry, recovery, and debugging flows.

error-translator

laolaoshiren/claude-code-skills-zh

编程错误消息翻译专家 — 将英文错误消息翻译成中文，解释原因并提供修复方案

errors

yonatangross/orchestkit

Error pattern analysis and troubleshooting for Claude Code sessions. Use when handling errors, fixing failures, troubleshooting issues.

erstantwort-generator

Klotzkette/claude-fuer-deutsches-recht

Hauptskill: erstellt die formelle Erstantwort-E-Mail an einen potenziellen Mandanten. Enthaelt Dank fuer die Anfrage, exakte Anrede aus der Eingangsmail, Hinweis auf telefonische Terminvergabe, Bitte um Sachverhaltsschilderung per E-Mail, Hinweis auf den Transkriptionsservice mit DSGVO-Einwilligungserfordernis, Mandatsverhaeltnis-Disclaimer und Schlussformel. Laedt wenn der Nutzer 'Erstantwort schreiben', 'Antwortmail erstellen', 'Eingangsbestaetigung', 'Erstreaktion Mandant' oder 'Antwort auf Anfrage' sagt.

erstgespraech-mandatsannahme

Klotzkette/claude-fuer-deutsches-recht

Strukturierter Erstgespraechsleitfaden fuer Agrar-, Forst- und Lebensmittelrecht: Erfassung der Konstellation, Konflikt- und GwG-Check, Vollmacht, Streitwert/Gebuehrenvereinbarung, Fristen-Erstprognose und Handlungsweichen.

erstgespraech-und-mandatsannahme

Klotzkette/claude-fuer-deutsches-recht

Mandatsannahme im Zeugnisrecht. Eingangsbestaetigung an den Mandanten mit Dank fuer das uebersandte Zeugnis, Anforderung der noch fehlenden Unterlagen (Arbeitsvertrag, Aenderungsvereinbarungen, Kuendigungsschreiben, Vorzeugnisse, Aufgabenbeschreibung, Beurteilungen, Krankheits- und Fehlzeitenuebersicht, Abmahnungen, Schriftwechsel zum Zeugnis). Strukturiertes Erstgespraech mit Zielklaerung, Fristen, Vergleichsbereitschaft, Vergueterungsvereinbarung und Hinweis auf Beweislast.

es5-compliance

serac-labs/serac

Enforce ES5-only syntax for ServiceNow server-side scripts (Rhino engine) — convert const/let, arrow functions, template literals, destructuring, for-of, and async/await to ES5 equivalents.

escalate

Kastalien-Research/thoughtbox

Format a structured escalation to the human decision-maker (Chief Agentic). Use when hitting an escalation threshold.

escalation-brief

vm0-ai/vm0-skills

Prepare structured escalation packages for engineering, product, security, or leadership with reproduction steps, business impact, and full context. Activate when a support issue needs to go beyond the support team, when writing an escalation document, when evaluating whether a problem warrants escalation, or when tracking follow-through after handing off an issue.

escalation-flagger

anthropics/claude-for-legal

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escalation-manager

modu-ai/cowork-plugins

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escalation-memo

t0ddc3by/claude-for-customer-success

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escalation-policy

microsoft/agent-framework

When and how to escalate Contoso Outdoors customer-support tickets.

escalations-and-incidents

Significant-Gravitas/skills-catalog

Use when a case is hot, VIP, legal, safety, fraud, or breaching: rate the severity, build the packet, and page the right path — never a guess upward.

escape-technique

yogsoth-ai/de-anthropocentric-research-engine

Identify dominant thinking pattern and escape it via deliberate pattern-breaking.

esg-greenwashing-csrd

Klotzkette/claude-fuer-deutsches-recht

Unternehmen muss ESG-Bericht erstellen oder verteidigt Greenwashing-Vorwurf. CSRD VO 2022/2464 gestaffelt seit 2024 ESRS-Standards Doppelte Wesentlichkeit EU-Taxonomie VO 2020/852 SFDR. Normen UWG § 5 Irrefuehrung BGH I ZR 252/22 klimaneutral EU-Green-Claims-Richtlinie 2024. Pruefraster Nachhaltigkeitsbericht-Pflicht Wesentlichkeitsanalyse Greenwashing-Risiko-Check. Output ESG-Bericht-Struktur Greenwashing-Verteidigung Werbe-Substantiierung. Abgrenzung zu lksg-csddd-lieferkettensorgfalt (Lieferkette) und umweltrecht-transaktionen-dd (M&A).

esg-reporting

mkurman/zorai

ESG (Environmental, Social, Governance) reporting and analytics. SASB, TCFD, GRI, and CDP frameworks. Carbon accounting, supply chain sustainability, diversity metrics, and regulatory disclosure support.

esignatures-io-automation

ComposioHQ/awesome-claude-skills

"Automate Esignatures IO tasks via Rube MCP (Composio). Always search tools first for current schemas."

eskalations-marker

Klotzkette/claude-fuer-deutsches-recht

Ordnet ein Vertragsproblem dem richtigen Genehmiger per Eskalationsmatrix aus dem Praxisprofil zu und erstellt die Genehmigungsanfrage. Laden, wenn der Nutzer fragt „wer muss das genehmigen\", „eskalieren\", „braucht das GC-Freigabe\", „Genehmigung einholen\" oder ein anderer Skill ein Problem identifiziert, das die Kompetenz des Prüfers übersteigt.

eslint

TerminalSkills/skills

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eslint-configuration

TheBushidoCollective/han

Use when eSLint configuration including config files, extends, plugins, and environment setup.

eslint-custom

TheBushidoCollective/han

Use when custom ESLint rules and plugins including rule development, AST traversal, and publishing.

eslint-fix

laolaoshiren/claude-code-skills-zh

安全诊断并修复 ESLint error、warning 和配置兼容问题。用于用户要求运行 lint、解释 ESLint 报错、限定范围自动修复或迁移 ESLint 配置时；优先使用项目锁定的包管理器与版本，先预检再修改，不自动下载最新版或批量改写无关源码。

eslint-plugin-custom-rule

coinbase/cds

USE THIS when asked to create a new eslint plugin rule for the eslint-plugin-cds package

eslint-rules

TheBushidoCollective/han

Use when eSLint built-in rules including rule configuration, severity levels, and disabling strategies.

esm

K-Dense-AI/scientific-agent-skills

Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable inference.

esm-protein-language-model

jaechang-hits/SciAgent-Skills

Protein language models (ESM3, ESM C) for sequence generation, structure prediction, inverse folding, and embeddings. Design novel proteins, extract ML features, or fold sequences. Local GPU or EvolutionaryScale Forge API. Use AlphaFold for traditional folding; RDKit for small molecules.

ESPHome

tonylofgren/aurora-smart-home

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espocrm

bobmatnyc/claude-mpm-skills

Comprehensive guide for developing on EspoCRM - metadata-driven CRM with service layer architecture

espocrm-automation

ComposioHQ/awesome-claude-skills

"Automate Espocrm tasks via Rube MCP (Composio). Always search tools first for current schemas."

esputnik-automation

ComposioHQ/awesome-claude-skills

"Automate Esputnik tasks via Rube MCP (Composio). Always search tools first for current schemas."

essays-in-persuasion-keynes

simbajigege/book2skills

Apply Keynes policy reasoning. Trigger on: "will austerity work?", "inflation or deflation?", "analyze this economic crisis".

establishing-project-context

GanyuanRan/Aegis

Use when the user asks to establish shared project language or project work exposes a resolved, vague, conflicting, renamed, or deprecated domain term that needs active semantic modeling.

estate-and-tax-brief

anthropics/claude-for-financial-advisors

Prepare a meeting-ready estate and tax brief for a household: opens with what was discussed and actioned since the last meeting, in the CRM (Wealthbox/Redtail/Salesforce), pulls the estate plan from the estate platform (Wealth.com: structure, signed status per document, balance sheet) plus the prior-year tax look-back and that year's tax constants, and cross-checks that against account titling and beneficiaries at the custodian, portfolio and alts platforms (Orion Connect/Addepar/CAIS/iCapital), surfacing unfunded trusts, titling mismatches and beneficiary gaps as prioritized flags. The only write is optional advisor-approved CRM follow-up tasks, shown for approval first. Never drafts trust language, gives legal advice, retitles an account or changes a beneficiary. Triggers on "estate brief", "estate meeting brief", "estate and tax brief", "estate plan review for [client]", "check [client]'s trust funding", "are [client]'s beneficiaries up to date", or "does [client]'s estate plan match their accounts".

estimate

pixel-cellar/Claude-Code-Game-Studios

通过分析复杂度、依赖关系、历史速度和风险因素来估算任务工作量。生成包含置信水平的结构化估算。

estimate-builder

datadrivenconstruction/DDC_Skills_for_AI_Agents_in_Construction

Build construction project estimates. Generate detailed cost breakdowns with labor, materials, equipment, and overhead.

estimation-fermi

lyndonkl/claude

Decomposes complex unknowns into estimable components to produce rapid order-of-magnitude answers with bounded uncertainty. Use when making quick estimates (market sizing, resource planning, feasibility checks), bounding unknowns with upper/lower limits, sanity-checking strategic assumptions, or when user mentions Fermi estimation, back-of-envelope calculation, order of magnitude, ballpark estimate, or triangulation.

estimation-planning

Tibsfox/gsd-skill-creator

Project estimation and scheduling techniques for software development. Covers work breakdown structures (WBS), critical path method (CPM), PERT three-point estimation, Gantt charts, resource leveling, Goldratt's critical chain project management (buffer management), story point estimation, planning poker, reference class forecasting (Kahneman/Flyvbjerg), cone of uncertainty, schedule compression (crashing vs. fast-tracking), milestone planning, dependency management, and Brooks's Law. Connects GSD wave execution planning as a practical estimation and scheduling framework.

etermin-automation

ComposioHQ/awesome-claude-skills

"Automate Etermin tasks via Rube MCP (Composio). Always search tools first for current schemas."

etetoolkit

K-Dense-AI/scientific-agent-skills

Phylogenetic tree toolkit (ETE). Tree manipulation (Newick/NHX), evolutionary event detection, orthology/paralogy, NCBI taxonomy, visualization (PDF/SVG), for phylogenomics.

etf-analysis

HKUDS/Vibe-Trading

ETF分析：产品筛选、费率对比、跟踪误差、流动性评估、策略应用与中国市场ETF量化配置框架。

ethers-js

TerminalSkills/skills

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etherscan

TermiX-official/cryptoclaw

Query block explorer APIs (Etherscan, BSCScan, Polygonscan, etc.) for transactions, contracts, and gas data.

ethical-hacking-methodology

benjaminasterA/antigravity-awesome-skills

This skill should be used when the user asks to \"learn ethical hacking\", \"understand penetration testing lifecycle\", \"perform reconnaissance\", \"conduct security scanning\", \"exploit ...

ethics

Tibsfox/gsd-skill-creator

Ethical theory and moral reasoning across the major philosophical traditions. Covers normative ethics (consequentialism, deontology, virtue ethics, care ethics, existentialist ethics), metaethics (moral realism, anti-realism, emotivism, error theory), and applied ethics (bioethics, environmental ethics, AI ethics, just war theory). Includes a moral dilemma analysis framework with worked examples applying multiple frameworks to the same case.

ethics-and-practice

Tibsfox/gsd-skill-creator

Religious ethics and practice across traditions — moral theology and its sources, the role of virtue, law, and narrative in ethical formation, ritual as ethical shaping, the relation of contemplative practice to ethical life, and comparative work on shared ethical ground (the golden rule, non-harm, care for the stranger) and genuine disagreement. Use when a query asks what a tradition requires of its adherents, how ritual and ethics interact, or how traditions agree and differ on specific moral questions.

ethics-governance

Tibsfox/gsd-skill-creator

Bias detection and mitigation, fairness metrics, privacy frameworks, consent models, transparency requirements, and accountability structures for data science practice. Covers algorithmic bias sources, disparate impact testing, differential privacy, GDPR principles, model cards, datasheets for datasets, responsible AI frameworks, and the organizational governance needed to make ethics actionable. Use when auditing models for bias, designing privacy-preserving systems, establishing governance processes, or evaluating the social impact of data-driven decisions.