anthropics/life-sciences.

binder-gauntlet

Validation and developability gauntlet for de novo designed protein binders and miniproteins against any protein target. Use this skill when designed binders are scored only by structure-predictor confidence (ipSAE, ipTM, pAE) and you must validate binding with independent re-prediction, pose agreement (DockQ) and controls, profile developability and sequence liabilities, check specificity and cross-reactivity, and write a validation dossier before you rank, filter or finalise binder designs, and at every selection round of a design campaign to steer it. Use when a user says "validate these binder designs", "run the gauntlet on these", "check developability" or "sequence liabilities", asks which designs should go to the lab, or asks for controls, a specificity panel or a validation dossier for designed binders.

clinical-trial-forecast

Forecasts one registered clinical trial's probability of success from registry records and documents the user supplies: checked research, a critiqued Monte Carlo model, a cited report and a claim ledger. Runs in Claude Science with Delegation on. Use when the user asks for a trial's probability of success, asks whether a named trial (an NCT id) will meet its primary endpoint, or asks to run the clinical-trial-forecast skill.

clinical-trial-protocol-skill

Generate clinical trial protocols for medical devices or drugs. This skill should be used when users say "Create a clinical trial protocol", "Generate protocol for [device/drug]", "Help me design a clinical study", "Research similar trials for [intervention]", or when developing FDA submission documentation for investigational products.